The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 2020
Filed:
Dec. 21, 2017
Jiangsu Aosaikang Pharmaceutical Co., Ltd., Nanjing, Jiangsu, CN;
Zaiwei Zong, Nanjing, CN;
Qian Zhao, Nanjing, CN;
Ruifeng Yang, Nanjing, CN;
Gan Li, Nanjing, CN;
Chao Yi, Nanjing, CN;
Haixi Zhu, Nanjing, CN;
JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD., Nanjing, Jiangsu, CN;
Abstract
A method for preparing a β-nucleoside compound, including the following steps: 1) performing a silylation reaction of a nitrogenous base or an analogue thereof in the presence of TMSOTf to give the nitrogenous base or the analogue thereof being protected by trimethylsilyl; 2) performing a direct glycosylation reaction of the reaction liquid, without being isolated, and a five- or six-membered ring saccharide or a derivative thereof closed by a hydroxyl protecting group to give a closed β-nucleoside compound; and 3) performing a deprotection reaction to give the β-nucleoside compound. The method uses a one-pot process to prepare the key intermediates of the β-nucleoside compound, and the yield of materials in β-configuration increases significantly. The method has the benefits of simple operations, being energy conservation and environment protection, and being suitable for industrial applications.