Zahid Yaqoob

Title: Zahid Yaqoob: Innovator in Optical Sensing and Imaging Technologies

Introduction

Zahid Yaqoob is a prominent inventor based in Cambridge, MA (US), known for his groundbreaking work in optical sensing and imaging technologies. With a total of 6 patents to his name, Yaqoob has made significant contributions to the fields of neuroscience and biomedical applications.

Latest Patents

One of his latest inventions is the Phase Cancellation Microscopy system. This high phase sensitivity wide-field phase cancellation interferometry system allows for single-shot, label-free optical sensing of neural action potentials by imaging optical path length changes. The ability to monitor single neurons within a neural network enhances our understanding of neural network processing, which is crucial for advancements in neuroscience and its biomedical applications. The system improves sensitivity by two orders of magnitude by canceling the phase profile of resting neurons from that of spiking neurons. Additionally, using a detector with a large well depth and an appropriately biased interferometer increases sensitivity by another order of magnitude, resulting in measurements that are three orders of magnitude more sensitive than those achievable with other microscopes.

Another notable invention is the 3-D Holographic Imaging Continuous Flow Cytometry system. This technology utilizes the refractive index of biological specimens as a source of intrinsic contrast, eliminating concerns about photobleaching or harmful effects from additional contrast agents. The system provides a 3-D refractive index map of continuously flowing biological samples in a micro-fluidic channel without any moving parts, offering rich information related to cellular metabolism at both cellular and subcellular levels.

Career Highlights

Zahid Yaqoob has worked with prestigious institutions such as the Massachusetts Institute of Technology and the California Institute of Technology. His work has significantly impacted the fields of optical sensing and imaging, paving the way for innovative applications in neuroscience and beyond.

Collaborations

Throughout his career, Yaqoob has collaborated with notable colleagues, including Changhuei Yang and Niyom Lue. These collaborations have further enriched his research and contributed to the advancement of optical technologies.

Conclusion

Zahid Yaqoob's innovative contributions to optical sensing and imaging technologies have positioned him as a leading figure in his field. His inventions not only enhance our understanding of neural processes but also hold promise for future biomedical applications.