The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 02, 2020

Filed:

Feb. 05, 2014
Applicant:

Massachusetts Institute of Technology, Cambridge, MA (US);

Inventors:

Yongjin Sung, Boston, MA (US);

Niyom Lue, Nahant, MA (US);

Zahid Yaqoob, Cambridge, MA (US);

Ramachandra Dasari, Shererville, IN (US);

Peter T. C. So, Boston, MA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G03H 1/04 (2006.01); G01N 15/14 (2006.01); G03H 1/08 (2006.01); G01N 21/53 (2006.01); G01N 21/64 (2006.01); G03H 1/00 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1434 (2013.01); G01N 15/1475 (2013.01); G01N 21/53 (2013.01); G01N 21/64 (2013.01); G03H 1/0443 (2013.01); G03H 1/0866 (2013.01); G01N 15/1484 (2013.01); G01N 2015/1445 (2013.01); G03H 2001/005 (2013.01); G03H 2001/0033 (2013.01); G03H 2001/0445 (2013.01); G03H 2210/12 (2013.01);
Abstract

Refractive index of biological specimens is a source of intrinsic contrast that can be explored without any concerns of photobleaching or harmful effects caused by extra contrast agents. This feature also contains rich information that can be related to the metabolism of cells at the cellular and subcellular levels. The present invention relates to systems and methods that can provide, without any moving parts, the 3-D refractive index map of continuously flowing biological samples in a micro-fluidic channel, for example.


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