Yung-Hsiang Kao

Title: Innovations and Patents of Yung-Hsiang Kao

Introduction

Yung-Hsiang Kao, based in San Mateo, CA, is a notable inventor in the field of biochemistry and molecular biology, holding an impressive portfolio of 19 patents. His innovations focus on significant advancements in polypeptide production and antibody variants, contributing to the fields of pharmaceuticals and biotechnology.

Latest Patents

One of Yung-Hsiang Kao's latest patents is titled "Prevention of disulfide bond reduction during recombinant production of polypeptides." This invention outlines methods to prevent the reduction of disulfide bonds during the harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures. This is a crucial advancement for maintaining the structural integrity of essential therapeutic proteins.

Another notable patent pertains to "Pertuzumab variants and evaluation thereof." This application discloses several variants of the monoclonal antibody Pertuzumab, including an unpaired cysteine variant, afucosylated variants, and different molecular weight species. The patent details methods for making and characterizing these variants and compositions, paving the way for potential improvements in cancer treatment efficacy.

Career Highlights

Throughout his career, Yung-Hsiang Kao has made significant impacts at prominent companies such as Genentech, Inc. His work has not only advanced scientific understanding but has also led to the development of innovative solutions in biotechnology.

Collaborations

Yung-Hsiang Kao has collaborated with esteemed professionals in his field, including Michael W. Laird and Melody Trexler Schmidt. These collaborations have fostered a dynamic environment for research and innovation, resulting in valuable contributions to the scientific community.

Conclusion

Yung-Hsiang Kao's commitment to innovation in polypeptide production and antibody variant development solidifies his position as an influential inventor. His continued contributions to biotechnology through his patents represent significant advancements in the industry, underscoring the importance of research and collaboration in driving innovation.