Company Filing History:
11 out of 950 
1 out of 1,061 
1 out of 989 
Years Active: 2001-2025
Title: Yuji Hori - Pioneering Innovator in Antigen-Binding Molecules
Introduction
Yuji Hori, based in Shizuoka, Japan, is a renowned inventor with a remarkable record of 10 patents. His innovative work primarily focuses on the development of advanced methods for producing polypeptide hetero-oligomers and creating anti-CD137 antigen-binding molecules that have significant implications in immunotherapy.
Latest Patents
Two of Yuji Hori's latest patents showcase his contributions to biochemistry and immunology. The first patent, titled "Method for Producing Polypeptide Hetero-Oligomer," aims to provide an efficient and stable method for producing heteromultimers. This method involves incubating homo variants of multiple types of heavy chain constant region-containing polypeptides, differing in antigen-binding activity, under conditions that allow for the reorganization of inter-polypeptide disulfide bonds, specifically ensuring that amino acid residues in the core hinge regions do not form disulfide bonds.
The second patent, "Anti-CD137 Antigen-Binding Molecule and Utilization Thereof," focuses on creating anti-CD137 antigen-binding molecules that possess immunocyte-activating effects and anti-tumor activities while minimizing impacts on normal tissues, thus reducing side effects. This innovation also explores how the binding activity of these molecules to CD137 can depend on various substances, such as small molecule compounds, within target tissues.
Career Highlights
Throughout his career, Yuji Hori has worked for notable companies, including Chugai Pharmaceutical Co., Ltd. and Sanshin Kogyo Co., Ltd. His expertise and innovations have significantly advanced the fields of immunology and pharmaceutical sciences, marking him as a key figure in the industry.
Collaborations
Yuji has collaborated with esteemed professionals in his field, including Tomoyuki Igawa and Hitoshi Katada. These partnerships have further enriched his research and development endeavors, fostering innovation in the creation of therapeutic molecules.
Conclusion
Yuji Hori stands out as a significant contributor to the field of biochemistry through his innovative inventions and patents. His groundbreaking work in antigen-binding molecules and methods for producing polypeptide hetero-oligomers not only highlights his ingenuity but also sets the foundation for future advancements in immunotherapy and related fields.