Yue Yun

Title: Innovations by Yue Yun: Pioneering Microfluidic Technologies

Introduction

Yue Yun, an accomplished inventor based in Johnston, IA, has made significant strides in the field of microfluidics with a total of 14 patents to her name. Her groundbreaking work focuses on innovative methods and devices that enhance cell analysis and transfection techniques, significantly impacting areas such as gene therapy and regenerative medicine.

Latest Patents

Yue Yun's most recent patents include:

1. **Microfluidic Label-Free Isolation and Identification of Cells Using Fluorescence Lifetime Imaging (FLIM)**

This patent discloses methods and devices for single-cell analysis utilizing fluorescence lifetime imaging microscopy (FLIM). The innovative microfluidic devices employ traps to immobilize cells, enabling detailed FLIM analysis. The method allows for sorting of plant, animal, or bacterial cells before or after imaging. Furthermore, the analysis of FLIM data is enhanced through a phasor plot, assisting in identifying metabolic patterns of individual cells.

2. **Microfluidic Systems and Methods for Lipoplex-Mediated Cell Transfection**

This groundbreaking patent outlines systems and methods for transfection facilitated by a microfluidic device. In this system, microdroplets encapsulate cells, transfection molecules, and a cationic lipid transfection reagent. The chaotic advection within the rendering channel aids in forming a uniform lipid-DNA complex, which significantly boosts gene delivery efficacy. This innovative approach also increases membrane permeability through shear stress, ultimately improving transfection efficiency. The applications for this technology are extensive, including in gene therapy, in vitro fertilization, regenerative medicine, cancer treatment, and vaccine development.

Career Highlights

Yue Yun has held significant positions in renowned organizations which have allowed her to contribute meaningfully to advancements in biotechnology. Notably, she has worked with Pioneer Hi-Bred International, Inc. and the University of California. Through her roles, she has gained valuable insights and experiences which have informed her inventive processes.

Collaborations

In her innovative journey, Yue has collaborated with talented individuals including Justin Schares and Randal Arnold. These partnerships have undoubtedly enriched her research and development efforts, leading to the creation of cutting-edge technologies in her field.

Conclusion

Yue Yun's inventive contributions and relentless pursuit of innovation have positioned her as a leading figure in the realm of microfluidics. With 14 patents, her work not only drives advancements in scientific research but also enhances practical applications in medicine and biotechnology. As she continues to innovate, the future holds promising potential for even greater advancements that may reshape the landscape of cellular analysis and treatment methodologies.