Yuanjun Sun

Title: Innovations of Yuanjun Sun in Heparin Synthesis

Introduction

Yuanjun Sun is a notable inventor based in Jinan, China. He has made significant contributions to the field of biochemistry, particularly in the synthesis of heparin. His innovative work has led to advancements in the production of heparin skeleton synthase, which has important applications in medicine.

Latest Patents

Yuanjun Sun holds a patent for a heparin skeleton synthase and its mutants. The patent describes a heparin skeleton synthase that originates from a specific amino acid sequence, as shown in SEQ ID NO.2, and a nucleotide sequence of the coding gene, as shown in SEQ ID NO.1. This recombinant expression level is 6.8 times that of the existing heparin skeleton synthase KfiA from K5. Additionally, the total enzyme activity per fermentation liquor is 5.22 times that of the heparin skeleton synthase KfiA. The mutants obtained through site-directed mutagenesis at various sites in the amino acid sequence exhibit high expression levels.

Career Highlights

Yuanjun Sun has worked at prestigious institutions, including Shandong University and Bloomage Biotechnology Corporation Limited. His research has focused on enhancing the efficiency of heparin synthesis, which is crucial for various medical applications.

Collaborations

Yuanjun has collaborated with notable colleagues, including Juzheng Sheng and Xueping Guo, who have contributed to his research endeavors.

Conclusion

Yuanjun Sun's innovative work in the field of heparin synthesis has led to significant advancements in biochemistry. His contributions are paving the way for improved medical applications and further research in this vital area.