Yuanhui Li

Title: Innovations of Yuanhui Li in Nucleic Acid Detection

Introduction

Yuanhui Li is an accomplished inventor based in Davis, California. He has made significant contributions to the field of biosensors, particularly in the detection and purification of nucleic acid biomarkers. His innovative work has the potential to impact various applications in medical diagnostics and research.

Latest Patents

Yuanhui Li holds a patent for an invention titled "Integrated electrochemical detection and purification of nucleic acid biomarkers." This biosensor platform apparatus and method can detect, purify, and identify nucleic acid (DNA and RNA) biomarkers in complex biological fluids. The methods utilize a two-stage molecular-based approach. The first stage screens for specific nucleic acid-based biomarkers through electrochemical detection of DNA:RNA hybridization, facilitating the removal of remaining complex media constituents. This stage employs probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids by single-molecule conductance measurements via break junction scanning. Identification can be enhanced with a library of conductance measurements. The methods provide strain-level information that can be used to identify antimicrobial resistance in detected pathogens. Additionally, the collection of RNA targets allows for biomarker detection and identification without the need for amplification, providing insights into the viability of the sample organism.

Career Highlights

Yuanhui Li is affiliated with the University of California, where he continues to advance research in biosensor technology. His work is characterized by a commitment to innovation and excellence in the field of molecular diagnostics.

Collaborations

Yuanhui Li collaborates with notable colleagues, including Erkin Seker and Joshua Hihath, who contribute to his research endeavors and enhance the impact of his inventions.

Conclusion

Yuanhui Li's innovative contributions to nucleic acid detection and purification exemplify the potential of biosensor technology in advancing medical diagnostics. His work not only addresses current challenges in the field but also paves the way for future innovations.