Company Filing History:
Years Active: 2010-2011
Title: Innovations of Inventor Yu Li in Cancer Research
Introduction: Yu Li, a prominent inventor based in Andover, Massachusetts, has significantly contributed to the field of cancer research through his groundbreaking innovations. With a total of three patents to his name, Yu Li's work focuses on the identification of novel phosphorylation sites that play a crucial role in various signaling pathways related to cancer.
Latest Patents: Yu Li's latest patents showcase his expertise in the science of phosphorylation. One notable invention involves tyrosine phosphorylation sites, where he discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia. This invention also includes peptides, such as AQUA peptides, that feature these phosphorylation sites, as well as antibodies specifically designed to bind to them. The potential diagnostic and therapeutic applications of these findings are profound.
Another significant patent pertains to reagents for detecting protein phosphorylation in EGFR-signaling pathways. This invention identifies 168 novel phosphorylation sites within signal transduction proteins and pathways, especially those involving the EGFR kinase. The patent provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for selective detection and quantification of the phosphorylated sites/proteins. The identified phosphorylation sites span various protein types, including actin-binding proteins, adaptor/scaffold proteins, and tumor suppressor proteins, among others.
Career Highlights: Yu Li is affiliated with Cell Signaling Technology, Inc., where he applies his expertise to further innovate in cancer research. His work has opened new avenues for understanding the complexities of signaling pathways and their implications in cancer biology.
Collaborations: Throughout his career, Yu Li has collaborated with esteemed colleagues such as Ailan Guo and Klarisa Rikova. Together, they have explored various aspects of protein phosphorylation and its significance in cancer therapies.
Conclusion: Yu Li's contributions to the field of cancer research through his innovative patents highlight his role as a key inventor in the scientific community. His work not only advances our understanding of cancer biology but also paves the way for potential diagnostic and therapeutic breakthroughs.
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