The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2010
Filed:
Jun. 21, 2007
Ailan Guo, Burlington, MA (US);
Kimberly Lee, Seattle, WA (US);
Klarisa Rikova, Reading, MA (US);
Charles Farnsworth, Concord, MA (US);
Albrecht Moritz, Salem, MA (US);
Yu LI, Andover, MA (US);
Robert Polakiewicz, Lexington, MA (US);
Ailan Guo, Burlington, MA (US);
Kimberly Lee, Seattle, WA (US);
Klarisa Rikova, Reading, MA (US);
Charles Farnsworth, Concord, MA (US);
Albrecht Moritz, Salem, MA (US);
Yu Li, Andover, MA (US);
Robert Polakiewicz, Lexington, MA (US);
Cell Signaling Technology, Inc., Danvers, MA (US);
Abstract
The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.