Company Filing History:
Years Active: 2010-2011
Title: The Innovative Contributions of Robert Polakiewicz
Introduction
Robert Polakiewicz is a notable inventor based in Lexington, MA (US). He has made significant contributions to the field of biochemistry, particularly in the area of protein phosphorylation. With a total of 2 patents, his work has advanced the understanding of kinase signaling pathways.
Latest Patents
Polakiewicz's latest patents include "Reagents for the detection of phosphorylated ATR kinase (Ser 428) and uses thereof." This invention discloses two novel phosphorylation sites in human ATR kinase, specifically serine 428 (Ser428) and serine 2317 (Ser2317). The invention provides reagents, including antibodies and AQUA peptides, that selectively bind to and detect ATR only when phosphorylated at these sites. Additionally, it offers methods for determining the phosphorylation of ATR kinase in biological samples using detectable reagents.
Another significant patent is "Reagents for the detection of protein phosphorylation in EGFR-signaling pathways." This invention identifies 168 novel phosphorylation sites in signal transduction proteins and pathways downstream of EGFR kinase. It provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides for the selective detection and quantification of these phosphorylated sites. The identified phosphorylation sites span various protein types, including actin binding proteins, adaptor proteins, and tumor suppressor proteins.
Career Highlights
Robert Polakiewicz is currently employed at Cell Signaling Technology, Inc., where he continues to innovate in the field of protein research. His work has been instrumental in developing tools that aid in the understanding of cellular signaling mechanisms.
Collaborations
Polakiewicz has collaborated with notable coworkers, including Ailan Guo and Kimberly A Lee, contributing to a dynamic research environment that fosters innovation.
Conclusion
Robert Polakiewicz's contributions to the field of biochemistry through his patents and work at Cell Signaling Technology, Inc. highlight his role as a key innovator in protein phosphorylation research. His inventions are paving the way for advancements in understanding cellular signaling pathways.
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