Youdong Pan

Title: Youdong PAN: Innovating Tumor Neoantigen Detection

Introduction

Youdong PAN is an esteemed inventor based in Shenzhen, China. He holds two patents that focus on advancements in the biomedical field, specifically related to tumor neoantigens. His innovative contributions aim to enhance the understanding and detection of immunogenicity in tumor neoantigens, thereby providing significant implications for cancer treatment and research.

Latest Patents

Youdong PAN's latest patents include:

1. **Method and System for Calculating Tumor Neoantigen Burden**

This patent introduces a comprehensive method for calculating tumor neoantigen burden (TNB). The process involves several key steps, starting with the processing of both normal and tumor samples. It includes sequencing specific regions, detecting somatic mutations, annotating, filtering, and eventually translating these mutations into mutant peptide sequences. The method further incorporates human leukocyte antigen (HLA) typing analysis to predict binding affinities between neopeptide sequences and the HLA genotypes, culminating in the calculation of TNB for the sample.

2. **Method and Platform for Detecting Immunogenicity of Tumor Neoantigen**

This innovation presents both a method and platform aimed at evaluating the immunogenicity of tumor neoantigens. The detection method consists of culturing human peripheral blood monocytes ex vivo for 13 days while adding antigenic peptide fragments and stimulating with immunoadjuvants. It culminates in an enzyme-linked immunospot (ELISPOT) chromogenic reaction, facilitating high-throughput assays for tumor neoantigen immunogenicity. This approach is notable for its short detection period, high convenience, and low operational costs.

Career Highlights

Youdong PAN has contributed significantly to the biomedical industry through his roles at leading companies. He has worked at Neocura Biomedical Technology Co., Ltd. and Beijing Neocurna Biotechnology Corporation, where he has collaborated on various projects aimed at enhancing cancer research and treatment methodologies.

Collaborations

Throughout his career, Youdong PAN has collaborated with several noted professionals, including Qi Song and Ji WAN. These partnerships have expedited the development of his innovative ideas and led to significant advancements in the field.

Conclusion

Youdong PAN is a remarkable inventor whose work on tumor neoantigen detection represents a significant stride in biomedical research. His patented methodologies provide vital tools for understanding immunogenicity, ultimately contributing to the enhancement of cancer therapies. His ongoing collaborations and professional endeavors continue to inspire innovations that hold the potential to transform cancer diagnosis and treatment.