The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 23, 2024
Filed:
Jan. 15, 2021
Shenzhen Neocura Biotechnology Corporation, Shenzhen, CN;
Ji Wan, Shenzhen, CN;
Yiming Shen, Shenzhen, CN;
Jian Wang, Shenzhen, CN;
Youdong Pan, Shenzhen, CN;
Yi Wang, Shenzhen, CN;
Qi Song, Shenzhen, CN;
Shenzhen NeoCura Biotechnology Corporation, Shenzhen, CN;
Abstract
A method and a system for calculating tumor neoantigen burden (TNB) are provided. The method includes: step S: processing a normal sample and a tumor sample, sequencing a specific region and detecting somatic mutations in the sample; step S: annotating and filtering the somatic mutations, and translating to obtain mutant peptide sequences of a patient; step S: filtering the mutant peptide sequences to obtain neopeptide sequences based on a proteome of the normal sample; step S, performing a human leukocyte antigen (HLA) typing analysis based on alignment data of the normal sample to obtain HLA genotypes of the sample; step S, predicting binding affinities between the neopeptide sequences and the HLA genotypes to obtain specific neoantigens of the sample, and performing a weighted scoring on each of the specific neoantigens and calculating the TNB of the sample.