Company Filing History:
12 out of 1,168 
1 out of 893 
Years Active: 1994-2018
Title: Yoram Shechter: Innovator in Reversible Pegylated Drugs
Introduction
Yoram Shechter is a prominent inventor based in Rehovot, Israel. He has made significant contributions to the field of pharmaceuticals, particularly in the development of innovative drug delivery systems. With a total of 12 patents to his name, Shechter's work has the potential to enhance the efficacy and safety of various therapeutic agents.
Latest Patents
One of Shechter's latest patents involves reversible pegylated drugs. These drugs are created by derivatizing free functional groups of selected drugs, such as amino, hydroxyl, mercapto, phosphate, and carboxyl groups, with sensitive groups like 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS). The unique aspect of these pegylated drugs is that the PEG moiety and the drug residue are not directly linked, allowing for a more controlled release under physiological conditions. This innovation is particularly beneficial for drugs containing amino groups, especially peptides and proteins of low to medium molecular weight.
Another notable patent by Shechter focuses on albumin binding probes and drug conjugates. This invention provides a long-chain fatty acid-like albumin-binding probe that enhances the associating affinity with human serum albumin. When conjugated with short-lived drugs containing amino or mercapto groups, this probe significantly prolongs the drug's lifespan without interfering with its pharmacological activity. The invention also includes pharmaceutical compositions and various uses of these conjugates.
Career Highlights
Throughout his career, Yoram Shechter has worked with esteemed organizations such as Yeda Research and Development Company and Yissum Research Development Company of the Hebrew University of Jerusalem. His work in these institutions has allowed him to push the boundaries of pharmaceutical research and development.
Collaborations
Shechter has collaborated with notable colleagues, including Matityahu Fridkin and Haim Tsubery. These partnerships have contributed to the advancement of his research and the successful development of his patented technologies.
Conclusion
Yoram Shechter's innovative work in reversible pegylated drugs and albumin binding probes showcases his commitment to improving drug delivery systems. His contributions to the pharmaceutical field are significant and continue to influence future research and development.