Location History:
- Walkersville, MD (US) (2023)
- Silver Spring, MD (US) (2023)
Company Filing History:
2 out of 592 
1 out of 24 
1 out of 1,373 
Years Active: 2023-2025
Title: The Innovative Contributions of Yonatan Levinson
Introduction
Yonatan Levinson is a notable inventor based in Walkersville, MD (US). He has made significant contributions to the field of bioprocessing, particularly in the automation of cell culture monitoring and control. With a total of 3 patents to his name, Levinson's work has the potential to revolutionize clinical manufacturing processes.
Latest Patents
One of Levinson's latest patents focuses on the automated control of cell culture using Raman spectroscopy. This innovation provides a method for monitoring and controlling bioprocesses by generating generic calibration models that are independent of cell lines. The use of inline Raman probes allows for the monitoring of critical parameters such as glucose, lactate, glutamate, ammonium, viable cell concentration (VCC), total cell concentration (TCC), and product concentration. The calibration models were developed using two different CHOK1SV GS-KO™ cell lines that produce distinct monoclonal antibodies (mAbs). Predictive models were qualified using an independent CHOK1SV GS-KO™ cell line not involved in the calibration process, demonstrating minor prediction errors throughout the cell culture process. This development enables the application of spectroscopic Process Analytical Technology (PAT) techniques in a clinical manufacturing environment, where processes are typically executed once or twice based on a common platform.
Career Highlights
Levinson has worked with prominent companies in the biopharmaceutical sector, including Lonza Inc. and Lonza Walkersville, Inc. His experience in these organizations has contributed to his expertise in bioprocessing and innovation in cell culture technologies.
Collaborations
Throughout his career, Levinson has collaborated with talented individuals such as Eytan Abraham and Thaddaeus Webster. These partnerships have further enhanced his contributions to the field.
Conclusion
Yonatan Levinson's innovative work in the automation of cell culture monitoring and control showcases his significant impact on bioprocessing. His patents and collaborations reflect a commitment to advancing technology in clinical manufacturing.