Yining Zhu

Title: Yining Zhu: Inventor in Viral Vector Production

Introduction

Yining Zhu is an inventor associated with Johns Hopkins University in Baltimore, Maryland. Her work includes a patent describing a formulation and preparation method for shelf-stable DNA/polyethyleneimine (PEI) particles intended to support viral vector production.

Latest Patents

Zhu is associated with 1 patent: “Composition of Shelf-Stable Plasmid DNA/Polyethyleneimine (PEI) Particles with Defined Sizes for Viral Vector Production and Method for Preparation of the Same.” The invention describes a scalable method for producing DNA/polycation particles of defined size, incorporating multiple virus-assembly plasmids for transfecting viral production cells in suspension cultures. The particles are designed to provide reproducible transfection activity and shelf stability in suspension, potentially enabling an off-the-shelf product. The formulation may simplify viral manufacturing and improve production quality and consistency.

Career Highlights

Zhu’s patent work is connected to Johns Hopkins University and focuses on a potential improvement to the preparation and use of plasmid particles in viral vector manufacturing. The disclosed approach emphasizes defined particle sizes, scalability, and storage stability.

Collaborations

The provided information identifies Hai-Quan Mao and Yizong Hu as Zhu’s coworkers. Their names are associated with the same research and patent context.

Conclusion

Yining Zhu’s patent contribution centers on shelf-stable, size-defined DNA/PEI particles that may help make viral vector production more scalable, consistent, and efficient.