Yingzhu Liu

Title: Innovations of Yingzhu Liu in Electrochemical Aptamer-Based Sensors

Introduction

Yingzhu Liu is a prominent inventor based in Miami, FL (US), known for his significant contributions to the field of electrochemical sensors. With a total of 5 patents, Liu has developed innovative methods that enhance the sensitivity and functionality of aptamer-based sensors.

Latest Patents

One of Liu's latest patents focuses on "Immobilization strategies for enhancing sensitivity of electrochemical aptamer-based sensors." This invention provides methods for fabricating electrochemical aptamer-based (E-AB) sensors that exhibit improved sensitivity, signal-to-noise ratios, limits of detection (LOD), and enhanced stability and reproducibility. The methods also include aptamer immobilization techniques that ensure optimal spacing between aptamers at the microscale, facilitating better target recognition, folding, and signal transduction. The E-AB sensors developed through this invention demonstrate superior sensing capabilities, regardless of the sequence or structure of the bound aptamers or the physiochemical properties of the target.

Another notable patent by Liu is titled "Methods for generating structure-switching aptamers and uses thereof." This invention outlines methods, assays, and products for detecting small-molecule targets in complex samples, applicable in both clinical and field settings. It introduces aptamer-based sensors and methods for their use, including exonuclease-based techniques for generating structure-switching aptamers from fully folded or pre-folded aptamers. The method allows for the detection of small-molecule targets in a sample by using aptamer-based sensors selective for each target.

Career Highlights

Yingzhu Liu is affiliated with Florida International University, where he continues to advance research in the field of electrochemical sensors. His work has garnered attention for its practical applications and innovative approaches to sensor technology.

Collaborations

Liu collaborates with esteemed colleagues such as Yi Xiao and Haixiang Yu, contributing to a dynamic research environment that fosters innovation and discovery.

Conclusion

Yingzhu Liu's contributions to the field of electrochemical aptamer-based sensors highlight his role as a leading inventor. His innovative patents and collaborative efforts continue to push the boundaries of sensor technology, making significant impacts in various applications.