Ying-Ju Sung

Title: Innovations of Ying-Ju Sung in Neuronal Pain Pathways

Introduction

Ying-Ju Sung is a prominent inventor based in Prospect Park, NJ (US). He has made significant contributions to the field of neuroscience, particularly in understanding the molecular mechanisms underlying pain pathways. With a total of 5 patents, his work has the potential to impact therapeutic approaches for persistent pain.

Latest Patents

One of Ying-Ju Sung's latest patents is focused on the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons. This invention highlights the role of nitric oxide synthase activity in increasing nitric oxide production, which activates guanylyl cyclase and elevates cGMP levels. The increased cGMP subsequently activates protein kinase G (PKG), leading to significant changes in neuronal function. Another important patent involves the development of compounds that inhibit the activation of PKG. This invention is based on the identification of the tertiary structure of PKG and the discovery of molecules that can bind to its active site or serve as analogs of balanol.

Career Highlights

Ying-Ju Sung is affiliated with Columbia University, where he conducts his research and develops his innovative ideas. His work has garnered attention for its potential applications in treating chronic pain conditions.

Collaborations

Ying-Ju Sung has collaborated with notable colleagues, including Richard Ambron and Shi-Xian Deng, to advance his research and explore new avenues in neuroscience.

Conclusion

Ying-Ju Sung's contributions to the understanding of neuronal pain pathways and the development of related therapeutic compounds underscore his role as an influential inventor in the field. His innovative work continues to pave the way for advancements in pain management.