The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 18, 2015
Filed:
Aug. 08, 2012
Richard Ambron, Lake Success, NY (US);
Ying-ju Sung, Prospect Park, NJ (US);
Donald W. Landry, New York, NY (US);
Shi-xian Deng, White Plains, NY (US);
Richard Ambron, Lake Success, NY (US);
Ying-Ju Sung, Prospect Park, NJ (US);
Donald W. Landry, New York, NY (US);
Shi-Xian Deng, White Plains, NY (US);
The Trustees of Columbia University in the City of New York, New York, NY (US);
Abstract
The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent pain. It is based on the discovery that, following injury to an axon of a neuron, an increase in nitric oxide synthase activity results in increased nitric oxide production, which, in turn, activates guanylyl cyclase, thereby increasing levels of cGMP. Increased cGMP results in activation of protein kinase G ('PKG'), which then is retrogradely transported along the axon to the neuron cell body, where it phosphorylates MAPKerk.