Location History:
- Nanjing, CN (2014 - 2016)
- Beijing, CN (2021 - 2022)
Company Filing History:
2 out of 27,108 
2 out of 3,086 
Years Active: 2014-2022
Title: Innovations of Ying Gu in Photodynamic Therapy
Introduction
Ying Gu is a prominent inventor based in Nanjing, China, known for his significant contributions to the field of photodynamic therapy. With a total of four patents to his name, he has developed innovative compounds that enhance the efficacy of cancer treatments. His work focuses on hypocrellin derivatives, which have shown promising results in producing reactive oxygen species for tumor inactivation.
Latest Patents
Ying Gu's latest patents include a hypocrellin derivative substituted both in a peri-position and in the 2-position by amino, along with its preparation method and applications. This invention reveals that the derivative has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 Mcm. Compared to unmodified hypocrellin, this derivative exhibits a significantly red-shifted absorption spectrum and improved molar extinction coefficient, allowing it to efficiently produce reactive oxygen species under photosensitive conditions. Additionally, it demonstrates a stronger ability to photodynamically inactivate tumor cells than first and second generation commercial photosensitizers.
Another notable patent is the monosubstituted or polysubstituted amphiphilic hypocrellin derivative, which also includes a preparation method and application. This derivative, substituted by groups containing PEG or quaternary ammonium salts, shows an obvious red shift in its absorption spectrum and enhanced molar extinction coefficient. It can efficiently produce singlet state oxygen and other reactive oxygen species, while also offering increased biocompatibility with cells or tissues. This innovation meets the requirements of various clinical drugs and addresses the challenges of different drug delivery methods.
Career Highlights
Ying Gu has worked with notable organizations such as Huawei Technologies Co., Limited and the Chinese Academy of Sciences. His experience in these institutions has contributed to his expertise in developing advanced therapeutic solutions.
Collaborations
Ying Gu has collaborated with esteemed colleagues, including Rui Hua and Zhangqing He, to further his research and innovations in the field of photodynamic therapy.
Conclusion
Ying Gu's innovative work in hypocrellin derivatives has the potential to revolutionize cancer treatment through enhanced photodynamic therapy. His contributions are paving the way for more effective therapeutic options in the fight against cancer.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.