Huawei Technologies Co., Limited

Chinese Academy of Sciences

Bgi Shenzhen

Ying Gu

Weimin Liu

Pengfei Wang

Yong Qiu

Rui Hua

Xiuli Zheng

Jianguang Yang

Jiasheng Wu

Zhangqing He

Tongqiang Cao

Hongyan Zhang

Yinggen Wu

Jiechao Ge

Anhu Huang

Ping Liu

Jun Xia

Zhu Zhu

Xiongbin Kang

The present invention discloses a hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d:  The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 Mcm. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition. In the same condition, the hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino involved in the present invention, when used as a photosensitizer, has a stronger ability to photo-dynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

Hypocrellin derivative substituted both in a peri-position and in 2-position by amino, preparation method, and application thereof

The invention discloses a monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and a preparation method and application thereof. The amphiphilic hypocrellin derivative substituted by a group containing PEG, a quaternary ammonium salt or the like prepared according to the invention has an obvious red shift in its absorption spectrum and a significantly enhanced molar extinction coefficient, compared with the parent hypocrellin, can efficiently produce singlet state oxygen and other reactive oxygen species under photosensitive conditions; has different amphiphilicities and increased biocompatibility with cells or tissues by regulating its hydrophilicity and hydrophobicity; can meet the requirements of different clinical drugs, and solves the requirements of different drug delivery methods for different drug hydrophilicity and lipophilicity. Under identical conditions, the amphiphilic hypocrellin derivative photosensitizer according to the invention has higher ability to photodynamically inactivate tumor cells than the first and second generation commercial photosensitizers.

Monosubstituted or polysubstituted amphiphilic hypocrellin derivative, and preparation method and application thereof

The application pertains to a method for an Ethernet power sourcing equipment to provide electric power to one or more Ethernet powered devices. A controlling apparatus determines a power supply mode of the Ethernet power sourcing equipment, and determines high-power Ethernet powered device(s) and low-power Ethernet powered device(s) among the Ethernet powered devices. The controlling apparatus sets a power supply priority for each of the Ethernet powered devices. In one power supply mode, the power supply priority of a high-power Ethernet powered device is same as or lower than the lowest priority of the low-power Ethernet powered device(s). When a new Ethernet powered device is connected to the Ethernet power sourcing equipment, the controlling apparatus determines whether to supply electric power to the new Ethernet powered device according to its power supply priority.

Power over ethernet method, apparatus, device, and system

The present disclosure discloses a method and an apparatus of power over Ethernet, and belongs to the field of communications. An Ethernet power sourcing equipment sets a power supply port to a sleep state, and sets a timer for the power supply port; enables the power supply port when the timer reaches a set time; and detects whether a powered device PD is connected to the power supply port, and if a PD is connected to the power supply port, triggers the power supply port to supply power to the PD; if no PD is connected to the power supply port, resets the power supply port to the sleep state, and sets the timer for the power supply port. Implementation of the present disclosure effectively reduces power consumption of the system and saves energy.

Method and apparatus of Power over Ethernet

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Nanjing, China

Ying Gu