Yihua Ma

Title: Yihua Ma: Innovator in Alpha-Synuclein Research

Introduction

Yihua Ma is a notable inventor based in Corona, CA (US), recognized for his contributions to the field of alpha-synuclein research. He holds a total of 3 patents, showcasing his innovative approach to addressing challenges in seed amplification assays.

Latest Patents

Yihua Ma's latest patents include significant advancements in the development of inert matrices for qualitative and semi-quantitative seed amplification assays. These inert matrices are designed to accurately reflect the absence of misfolded alpha-synuclein protein when used as a negative control. They allow for the aggregation of the alpha-synuclein substrate with seeds when used as a positive control, making them valuable for screening reagent competence. Additionally, he has developed an expression vector for the production of human alpha-synuclein protein or its conservative variants, which exhibit a decreased tendency to self-aggregate. This innovation includes optimized codons to avoid amino acid misincorporation, along with methods for purification of the expressed protein.

Career Highlights

Yihua Ma is currently employed at Amprion, Inc., where he continues to push the boundaries of research in his field. His work has been instrumental in advancing the understanding of alpha-synuclein and its implications in neurodegenerative diseases.

Collaborations

Throughout his career, Yihua has collaborated with talented individuals such as Luis Concha and Carly Farris, contributing to a dynamic research environment that fosters innovation and discovery.

Conclusion

Yihua Ma's contributions to alpha-synuclein research and his innovative patents highlight his role as a leading inventor in the field. His work not only advances scientific understanding but also paves the way for future developments in neurodegenerative disease research.