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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12220445 B1

PDFFull Text
Date of Patent:
Feb. 11, 2025

Filed:

Sep. 09, 2022

Inert matrices for qualitative and semi-quantitative seed amplification assays

Applicant:

Amprion, Inc., San Francisco, CA (US);

Inventors:

Luis Concha, San Diego, CA (US);

Carly Farris, San Diego, CA (US);

Yihua Ma, Corona, CA (US);

Hieu Huu Nguyen, San Diego, CA (US);

Assignee:

Amprion, Inc., San Francisco, CA (US);

Attorneys:

Kern Kendrick, LLC

Benjamen E. Kern

Charlemagne Kern

Primary Examiner:

Julie Ha

Assistant Examiner:

Kristina M Hellman

Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 31/185 (2006.01); A61K 38/17 (2006.01); A61K 38/38 (2006.01); A61K 39/395 (2006.01); A61P 1/00 (2006.01); A61P 1/04 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01);
U.S. Cl.
CPC ...
A61K 38/385 (2013.01); A61K 31/185 (2013.01); A61K 38/1774 (2013.01);
Abstract

Inert matrices for use with α-synuclein seed amplification assays (αS-SAAs) are provided. The inert matrices accurately reflect the absence of misfolded αS protein when used as a negative control, in the form of no, perceptively low, or delayed αS substrate self-aggregation, yet will readily permit aggregation of the αS substrate with seeds when used as a positive control. The inert matrices may be used to screen for αS-SAA reagent competence. The inert matrices may be used to dilute samples taken from peripheral biological matrices. Finally, the inert matrices may be used as a diluent for serial dilutions of αS-SAA samples, to enable semi-quantitative versions of αS-SAAs.

Find Patent Forward Citations

Concha, Luis. (2025). Inert matrices for qualitative and semi-quantitative seed amplification assays (U.S. Patent No. 12220445). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12220445

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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