Company Filing History:
Years Active: 2018-2025
Title: **Yi-Chun Hsiao: A Leading Innovator in Neurobiology**
Introduction
Yi-Chun Hsiao is an accomplished inventor based in San Mateo, California, renowned for his contributions to the field of neurobiology. With a total of seven patents, Hsiao is making significant strides in developing innovative therapies targeting neurodegenerative diseases and other conditions affected by immune system activities.
Latest Patents
Hsaio's latest patents include groundbreaking work on **Agonists of TREM2**. This application reveals certain antibodies specifically designed to bind to human TREM2 (triggering receptor expressed on myeloid cells 2). These antibodies serve as TREM2 agonists, selectively interacting with the stalk region of intact human TREM2 while avoiding soluble TREM2—whose cleavage occurs between residues H157 and S158. The antibodies have demonstrated the capability to bind with high specificity and potency, ranging from 10 nM to as low as 1-10 pM, while also showing promise in enhancing the survival of human microglia cells and boosting Aβ plaque formation. Moreover, they inhibit the shedding of soluble TREM2 in various models, which could lead to neuroprotective activities beneficial in treating neurodegenerative disorders.
Another significant patent under Hsiao's name involves **Anti-interleukin-33 antibodies and uses thereof**. This invention provides antibodies targeting interleukin-33 (IL-33) and outlines the methods for their application, showcasing the potential for therapeutic interventions in conditions driven by immune responses.
Career Highlights
Hsiao is currently affiliated with Genentech, Inc., where he leverages his expertise to drive innovations in therapeutic research. His contributions have positioned him as a vital figure in exploring the nuances of immune responses related to neurodegeneration.
Collaborations
Within his professional landscape, Yi-Chun Hsiao collaborates with notable colleagues including Dhaya Seshasayee and Feny Gunawan. These collaborations reflect the combined efforts of talented individuals dedicated to advancing scientific breakthroughs and addressing significant medical challenges.
Conclusion
Yi-Chun Hsiao exemplifies the spirit of innovation in the realm of neurobiology. Through his pioneering patents and collaborations, he is at the forefront of developing new therapies that may transform the future of treatment for neurodegenerative diseases and enhance our understanding of immune functions. His ongoing work not only represents individual excellence but also embodies the power of teamwork and innovation in scientific discovery.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.