Genentech, Inc.

Yi-Chun Hsiao

Dhaya Seshasayee

Philip E Hass

Menno Van Lookeren Campagne

Gerald R Nakamura

Meredith C Hazen

Martin Vanderlaan

Wenwu Zhai

Inn Huam Yuk

Nancy Chiang

Rajesh Vij

Jack Bevers, Iii

Rajita Khosla

Hongkang Xi

Feny Gunawan

Denise C Krawitz

Margaret S Lin

Judith Zhu-Shimoni

Isidro Hotzel

Zhonghua Lin

Benny Chih

Ainhoa Echeverria Larraza

David Verne Hansen

This application discloses, inter alia, certain antibodies that specifically bind to human TREM2 (triggering receptor expressed on myeloid cells 2). In some embodiments, the antibodies act as TREM2 agonists. In some embodiments, antibodies herein specifically bind to the stalk region of intact, human TREM2, without binding to soluble TREM2, which is the product of TREM2 cleavage between residues H157 and S158. In some embodiments, the antibodies act as TREM2 agonists, specifically bind to the stalk region of TREM2 with dissociation constants ranging from 10 nM to as low as 100-500 pM, 10-50 pM, or 1-10 pM, specifically bind to a TREM2 epitope spanning the H157-S158 cleavage site, and do not bind to soluble TREM2. In some embodiments, antibodies herein also inhibit shedding of soluble TREM2 in a human microglia cell model and in vivo in a mouse model, decrease levels of soluble TREM2 in plasma, CSF and/or the brain, enhance survival of human microglia cells, and increase Aβ plaque formation and compaction in a human microglia model (for example, as measured by increased Aβ plaque intensity and/or increased X04 plaque intensity in human microglia), and thus, may provide a number of neuroprotective activities.

Agonists of TREM2

The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.

Anti-interleukin-33 antibodies and uses thereof

Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.

Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products

Compositions and methods for detecting and quantifying host cells protein in cell lines and recombinant polypeptide products

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San Mateo, CA, United States of America

Yi-Chun Hsiao