Yaping Xue

Title: Innovative Contributions of Yaping Xue in Biocatalysis

Introduction: Yaping Xue is a prominent inventor based in Zhejiang, China, with a remarkable portfolio of 12 patents. His work primarily focuses on biocatalysis and the development of methods for preparing important biochemical compounds. Through his innovative approaches, he has significantly contributed to advancements in enzyme technology.

Latest Patents: Among his latest inventions, Yaping Xue has developed a method for asymmetrically preparing L-phosphinothricin via an oxidation-reduction reaction through biological multi-enzyme coupling. This method utilizes a highly efficient enzyme catalysis system that includes a D-amino acid oxidase mutant, which is engineered for superior catalytic performance in converting D,L-phosphinothricin into L-phosphinothricin. Notably, the mutant is acquired through specific site mutations, resulting in a higher conversion rate when using racemic D,L-phosphinothricin.

Another significant patent from Yaping Xue is a phosphinothricin dehydrogenase mutant, designed to enhance the enzymatic process. This invention includes a recombinant bacterium expressing the phosphinothricin dehydrogenase mutant, which can undergo synchronous directed evolution for improved efficiency. The one-pot multi-enzyme synchronous directed evolution method he proposed allows for the rapid screening of recombinant bacteria with enhanced catalytic activity, achieving a high conversion rate and selectivity.

Career Highlights: Yaping Xue's affiliation with Zhejiang University has positioned him at the forefront of research in biocatalysis. His groundbreaking methods exemplify innovative thinking in the biochemical field, showcasing his dedication to solving complex challenges through effective enzyme utilization.

Collaborations: Throughout his career, Yaping Xue has collaborated with talented individuals in his field, including Yuguo Zheng and Feng Cheng. These partnerships have fostered a creative environment for advancing research and expanding the potential applications of their discoveries.

Conclusion: Yaping Xue’s contributions to biocatalysis and enzyme engineering highlight his innovative spirit as an inventor. His recent patents exemplify the impact of his research on the preparation of essential biochemical substances, enhancing efficiency and selectivity in biochemical processes. Through his continued dedication to innovation, he paves the way for future advancements in the field.