Yao Nie

Title: Yao Nie: Innovator in Biochemical Synthesis

Introduction

Yao Nie is a prominent inventor based in Wuxi, China. He has made significant contributions to the field of biochemical synthesis, holding a total of 2 patents. His work focuses on the development of innovative methods and enzymes that enhance the efficiency of biochemical processes.

Latest Patents

Yao Nie's latest patents include groundbreaking inventions in the realm of dioxygenase mutants and stereospecific carbonyl reductases. One of his notable patents involves the creation of dioxygenase mutants that are utilized in synthesizing (2S,3R)-3-hydroxypipecolic acid. This invention is achieved by mutating arginine at position 97 and asparagine at position 43 of a wild type L-proline-3-hydroxylase. The resulting mutated L-proline-3-hydroxylase comprises a variant of the wild-type enzyme, featuring specific amino acid substitutions that enhance its functionality. Additionally, he has developed stereospecific carbonyl reductases, namely SCR1, SCR2, and SCR3, which exhibit anti-Prelog selectivity and are valuable for fine biochemical synthesis.

Career Highlights

Yao Nie has had a distinguished career, contributing to various research institutions. He has worked at Jiangnan University and Rutgers, the State University of New Jersey, where he has furthered his research in biochemical synthesis and enzyme development.

Collaborations

Throughout his career, Yao has collaborated with notable colleagues, including Yan Xu and Gaetano T Montelione. These collaborations have enriched his research and contributed to the advancement of his innovative projects.

Conclusion

Yao Nie is a remarkable inventor whose work in biochemical synthesis has led to significant advancements in the field. His innovative patents and collaborations highlight his dedication to enhancing biochemical processes through scientific research.