Company Filing History:
2 out of 5 
2 out of 2 Years Active: 2021-2022
Title: Yanlu Zan: Innovator in Bispecific Antibody Development
Introduction
Yanlu Zan is a prominent inventor based in Beijing, China. He has made significant contributions to the field of biotechnology, particularly in the development of bispecific antibodies. With a total of 2 patents, his work focuses on innovative treatments for tumor diseases and other medical conditions.
Latest Patents
Yanlu Zan's latest patents include the development of an anti-EGFR and anti-CD3 bispecific antibody. This invention provides a bispecific antibody that can specifically bind to the epidermal growth factor receptor (EGFR) on tumor cell surfaces and the CD3 molecule on immune cell surfaces. The single-chain antibody (ScFv) of the anti-CD3 antibody is strategically located at the C terminal of the constant region of the anti-EGFR antibody. The patent also details a preparation method for the bispecific antibody and its clinical applications. This bispecific antibody exhibits high affinity and is intended for treating tumor diseases associated with high or abnormal expression of EGFR.
Another significant patent by Yanlu Zan is the anti-PD-1 monoclonal antibody and its obtaining method. This invention provides human monoclonal antibodies that specifically bind to PD-1 with high affinity. The antibodies were screened from a synthetic antibody library, and affinity maturation was performed to enhance their effectiveness. These human anti-PD-1 monoclonal antibodies inhibit the binding of PD-1 to its ligand PD-L1, making them useful for treating tumors, inflammation, and autoimmune diseases.
Career Highlights
Throughout his career, Yanlu Zan has worked with notable companies such as Beijing Dongfang Biotech Co., Ltd. and Beijing Jingyitaixiang Technology Development Co. Ltd. His expertise in antibody development has positioned him as a key figure in the biotechnology sector.
Collaborations
Yanlu Zan has collaborated with esteemed colleagues, including Yi Bai and Shuang Pei. These partnerships have contributed to the advancement of his research and the successful development of innovative therapies.
Conclusion
Yanlu Zan's contributions to the field of biotechnology, particularly in bispecific antibody development, highlight his role as an influential inventor. His patents reflect a commitment to advancing medical treatments and improving patient outcomes.