The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2022
Filed:
Sep. 28, 2017
Beijing Dongfang Biotech Co., Ltd., Beijing, CN;
Beijing Jingyitaixiang Technology Development Co. Ltd., Beijing, CN;
Yi Bai, Beijing, CN;
Wen Zhang, Beijing, CN;
Meng Xu, Beijing, CN;
Shuang Pei, Beijing, CN;
Yanlu Zan, Beijing, CN;
Shengmei Wen, Beijing, CN;
BEIJING DONGFANG BIOTECH CO., LTD., Beijing, CN;
BEIJING JINGYITAIXIANG TECHNOLOGY DEVELOPMENT CO. LTD., Beijing, CN;
Abstract
An anti-Epidermal Growth Factor Receptor (EGFR) and anti-Cluster-of-Differentiation (CD3) bispecific antibody and uses thereof are provided. The bispecific antibody can specifically bind to antigen epidermal growth factor receptor (EGFR) on tumor cell surface and antigen CD3 molecule on immune cell surface. The single-chain antibody (ScFv) of an anti-CD3 antibody is located at the C terminal of the constant region of the anti-EGFR antibody. Further provided are a preparation method of the bispecific antibody and clinical applications of the bispecific antibody. The bispecific antibody has high affinity, and is used for treating tumor diseases caused by high expression or abnormal expression of the EGFR and other diseases caused by other overexpression of the EGFR.