Yan Wu

Title: Innovations and Contributions of Inventor Yan Wu

Introduction

Yan Wu is a prominent inventor based in La Jolla, California. She has made significant contributions to the field of biomedical engineering, particularly in the area of tissue engineering and genetic screening. With a total of three patents to her name, her work is at the forefront of innovative research.

Latest Patents

One of Yan Wu's latest patents is a method to engineer transplantable human tissues. This disclosure relates to various methods, polynucleotides, vectors, viral particles, cells, and systems for the engineering of human tissues. One aspect of this patent involves using lineage-specific miRNA binding molecules to bias tissue lineage. Another aspect focuses on using lineage-specific transcription factor overexpression to influence tissue lineage.

Another significant patent is related to methods for screening genetic perturbations. This work addresses the challenges of understanding the complex effects of genetic perturbations on cellular state and fitness in human pluripotent stem cells (hPSCs). The innovative approach utilizes barcoded open reading frame (ORF) overexpression libraries combined with single-cell RNA sequencing (scRNA-seq) and fitness screening, a technique referred to as SEUSS (ScalablE fUnctional Screening by Sequencing). This comprehensive platform allows for the systematic assay of mutant gene libraries and whole gene families, leading to the identification of key altered gene modules.

Career Highlights

Yan Wu is affiliated with the University of California, where she continues to advance her research and contribute to the scientific community. Her work has garnered attention for its potential applications in regenerative medicine and genetic research.

Collaborations

Throughout her career, Yan Wu has collaborated with notable colleagues, including Kun Zhang and Prashant G Mali. These collaborations have further enriched her research and expanded the impact of her innovations.

Conclusion

In summary, Yan Wu is an influential inventor whose work in tissue engineering and genetic screening is paving the way for future advancements in biomedical research. Her patents reflect her commitment to innovation and her contributions to the scientific community are invaluable.