Company Filing History:
Years Active: 2023-2025
Title: Xuan Guan: Innovator in Cardiac Research
Introduction
Xuan Guan is a prominent inventor based in Seattle, WA, known for his significant contributions to cardiac research. He has been awarded 2 patents that focus on innovative methods for treating cardiac diseases and advancing drug discovery platforms.
Latest Patents
One of his latest patents is titled "Engineering the RRM2 subunit of ribonucleotide reductase to resist degradation." This invention provides isolated nucleic acids that encode a stable form of Rrm2, which can be used to increase intracellular Rrm2 protein levels and cytosolic 2-deoxy-ATP (dATP) levels. The patent also outlines methods for treating cardiac diseases, such as myocardial infarction or myocardial ischemia, by administering these isolated nucleic acids or the polypeptides they encode.
Another notable patent is "Drug discovery platform for Duchenne cardiomyopathy." This invention includes methods for screening agents in a cardiomyocyte population differentiated from a dystrophin knockout iPSC line. The high-throughput methods allow for the assessment of agents' effects on membrane barrier function using cell viability assays. Additionally, the patent describes methods for creating dystrophin knockout iPSC lines and modeling dystrophin-deficient cardiomyopathy.
Career Highlights
Xuan Guan is affiliated with the University of Washington, where he conducts his research and development in the field of cardiac health. His work has been instrumental in advancing the understanding and treatment of cardiac disorders.
Collaborations
He collaborates with notable colleagues, including Michael Regnier and Charles E Murry, who contribute to his research efforts and innovations in cardiac science.
Conclusion
Xuan Guan's innovative work in cardiac research, particularly through his patents, showcases his commitment to improving treatment options for cardiac diseases. His contributions are paving the way for future advancements in the field.