The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2025
Filed:
Jun. 28, 2019
Applicant:
University of Washington, Seattle, WA (US);
Inventors:
Assignee:
UNIVERSITY OF WASHINGTON, Seattle, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/44 (2006.01); A61K 48/00 (2006.01); C12N 15/52 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 38/44 (2013.01); A61K 48/0066 (2013.01); C12N 15/52 (2013.01); C12N 15/86 (2013.01); C12Y 117/04001 (2013.01);
Abstract
Provided herein are isolated nucleic acids that encode a stable form of Rrm2 for the use of increasing the intracellular Rrm2 protein levels and cytosolic 2-deoxy-ATP (dATP) levels. Further provided herein are methods for treating a cardiac disease or disorder, e.g., myocardial infarction or myocardial ischemia, by administering the isolated nucleic acids, a polypeptide encoded by the isolated nucleic acids, or composition comprising the isolated nucleic acids to a subject in need thereof.