Xin Yu Koh

Title: Xin Yu Koh: Advancing Antibody Research for Mutant p53

Introduction

Xin Yu Koh is an inventor based in Singapore, SG, with 3 patents. His listed patent work focuses on antibodies that distinguish mutant p53 proteins from their wildtype counterparts, with potential applications in cancer research and care.

Latest Patents

The listed inventions titled “Anti-p53 antibodies” describe methods for producing antibodies specific to mutant p53 polypeptides. The methods use an immunogen containing an antigen sequence that includes the mutation and at least one adjacent amino acid, together with a scaffold sequence that presents the antigen in a solvent-accessible configuration.

One described approach uses mutant p53 as the immunogen and identifies thioredoxin as a possible scaffold. Specific embodiments generate antibodies against p53 variants R175H, R248Q, and R273H. The disclosed applications include cancer diagnosis, prognosis, patient-group stratification, imaging, and treatment.

Career Highlights

Koh’s listed organizational affiliations include the Agency for Science, Technology and Research and Singapore Health Services Pte Ltd. His patent work connects antibody development with the study of cancer-associated p53 mutations.

Collaborations

The listed collaborators include Le-Ann Hwang and David Philip Lane. Their names are associated with the research and patent work concerning anti-p53 antibodies.

Conclusion

Xin Yu Koh’s listed inventions focus on developing antibodies that selectively recognize mutant p53, with potential uses spanning cancer diagnosis, research, imaging, and treatment.