The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 14, 2025
Filed:
Feb. 22, 2023
Agency for Science, Technology and Research, Singapore, SG;
Singapore Health Services Pte. Ltd., Singapore, SG;
National University of Singapore, Singapore, SG;
Tr Kanaga Sabapathy, Singapore, SG;
David P. Lane, Singapore, SG;
Le-Ann Hwang, Singapore, SG;
Xin Yu Koh, Singapore, SG;
Liew Oi Wah, Singapore, SG;
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, Singapore, SG;
Singapore Health Services Pte Ltd, Singapore, SG;
NATIONAL UNIVERSITY OF SINGAPORE, Singapore, SG;
Abstract
The invention relates to methods for producing an antibody which is specific for a mutant p53 polypeptide over wildtype p53 polypeptide, comprising using as an immunogen a peptide or polypeptide comprising: (i) an antigen sequence, comprising an amino acid sequence of the mutant p53 polypeptide including the mutation and at least one amino acid immediately adjacent to the mutation, and (ii) a scaffold sequence for providing the antigen sequence in a solvent-accessible configuration. Also provided are antibodies produced by such methods, and uses thereof.