Xiaowei Li

Title: Innovations of Xiaowei Li in Neurodegenerative Disorders

Introduction

Xiaowei Li is an accomplished inventor based in Gainesville, FL (US). He has made significant contributions to the field of neurodegenerative disorders through his innovative research and patents. His work focuses on developing DNA aptamers that target tau proteins, which are crucial in understanding and treating tauopathy-related conditions.

Latest Patents

Xiaowei Li holds a patent titled "Tau protein-binding DNA aptamers with capture/detection and therapeutic utilities in tauopathy-related neurodegenerative disorders." This patent identifies DNA aptamers that bind to tau protein at its phosphorylatable sites. These aptamers not only recognize tau at specific sites but also exhibit inhibitory effects on tau protein phosphorylation and oligomer formation. The molecular probes derived from these DNA aptamers can be utilized as capture or detection agents to measure tau and phosphor-tau levels in cerebrospinal fluid. Additionally, they can be employed for cell-based or in vivo brain imaging in live animals or humans. The compositions containing these DNA aptamers have the potential to halt or treat the progression of tauopathy associated with neurodegenerative disorders.

Career Highlights

Xiaowei Li has worked with notable organizations, including the University of Florida Research Foundation and the United States Government as represented by the Department of Veterans Affairs. His research has garnered attention for its potential impact on the treatment of neurodegenerative diseases.

Collaborations

Xiaowei Li has collaborated with esteemed colleagues such as Ka W Wang and Weihong Tan. Their combined expertise has contributed to advancing research in the field of neurodegenerative disorders.

Conclusion

Xiaowei Li's innovative work in developing DNA aptamers for tau protein detection and therapeutic applications represents a significant advancement in the fight against neurodegenerative disorders. His contributions are paving the way for new diagnostic and treatment options in this critical area of research.