The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2020
Filed:
Sep. 29, 2017
University of Florida Research Foundation, Inc., Gainesville, FL (US);
Department of Veteran's Affairs, Washington, DC (US);
Ka W. Wang, Gainesville, FL (US);
Weihong Tan, Gainesville, FL (US);
Xiaowei Li, Gainesville, FL (US);
Hamad Yadikar, Gainesville, FL (US);
I-Ting Teng, Gainesville, FL (US);
University of Florida Research Foundation, Inc., Gainesville, FL (US);
Department of Veteran's Affairs, Washington, DC (US);
Abstract
DNA aptamers that bind to tau protein at its phosphorylatable sites are identified. These disclosed DNA aptamers not only recognize tau at specific phosphorylatable sites, but also demonstrate inhibitory effects on phosphorylation and oligomer formation of tau protein. Molecular probes based on these disclosed DNA aptamers can be used as capture or detection agents to detect the levels of tau and phosphor-tau in cerebrospinal fluid as well as for cell-based or in vivo brain imaging in live animals or human. Compositions comprising these disclosed DNA aptamers can be used to arrest or treat the progression of tauopathy associated neurodegenerative disorders.