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Title: Innovations of Ka W Wang in Neurodegenerative Disorders
Introduction
Ka W Wang is a notable inventor based in Gainesville, FL (US), recognized for his contributions to the field of neurodegenerative disorders. His innovative work focuses on the development of DNA aptamers that target tau proteins, which are crucial in understanding and treating tauopathy-related conditions.
Latest Patents
Wang holds a patent titled "Tau protein-binding DNA aptamers with capture/detection and therapeutic utilities in tauopathy-related neurodegenerative disorders." This patent identifies DNA aptamers that bind to tau protein at its phosphorylatable sites. The disclosed DNA aptamers not only recognize tau at specific phosphorylatable sites but also demonstrate inhibitory effects on the phosphorylation and oligomer formation of tau protein. Molecular probes based on these DNA aptamers can be utilized as capture or detection agents to measure the levels of tau and phosphor-tau in cerebrospinal fluid. Additionally, they can be employed for cell-based or in vivo brain imaging in live animals or humans. Compositions comprising these DNA aptamers can be used to arrest or treat the progression of tauopathy associated with neurodegenerative disorders.
Career Highlights
Throughout his career, Ka W Wang has worked with esteemed organizations, including the University of Florida Research Foundation and the United States Government as represented by the Department of Veterans Affairs. His innovative research has significantly contributed to the understanding of tau proteins and their implications in neurodegenerative diseases.
Collaborations
Wang has collaborated with notable colleagues such as Weihong Tan and Xiaowei Li, enhancing the impact of his research through shared expertise and knowledge.
Conclusion
Ka W Wang's innovative work in developing DNA aptamers for tau proteins represents a significant advancement in the field of neurodegenerative disorders. His contributions have the potential to lead to new diagnostic and therapeutic strategies for conditions associated with tauopathy.
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