Location History:
- Pittsburgh, PA (US) (1995)
- Waxford, PA (US) (2003)
- Wexford, PA (US) (2003 - 2009)
- Chapel Hill, NC (US) (1998 - 2023)
Company Filing History:
19 out of 1,274 
5 out of 1,869 
2 out of 11 
Years Active: 1995-2025
Title: Innovations of Xiao Xiao in Gene Therapy and AAV Technology
Introduction
Xiao Xiao is a prominent inventor based in Chapel Hill, NC, with an impressive portfolio of 26 patents. His work primarily focuses on advancements in gene therapy, particularly involving clotting factors and adeno-associated virus (AAV) technologies. Xiao's innovative spirit has contributed significantly to the field of biomedical research and treatment strategies for various disorders.
Latest Patents
Xiao's latest patents include groundbreaking inventions that enhance gene therapy approaches. One of them, titled "Optimized human clotting factor IX gene expression cassettes and their use," delves into synthetic liver-specific promoters and expression constructs designed for producing polypeptides and functional nucleic acids in the liver. This invention aims to create optimized polynucleotide sequences that encode Factor IX proteins, which are critical for treating bleeding disorders effectively.
Another significant patent, "Modified adeno-associated virus 5 capsids and uses thereof," introduces mutant AAV serotype 5 (AAV5) with enhanced capsid properties. These mutants exhibit increased infectivity in human liver cells while maintaining minimal binding to neutralizing antibodies. This invention encompasses libraries of mutant AAV5, methods for generating these mutants, and the recombinant AAV5 (rAAV5) virions that contain mutant capsid proteins, offering promising tools for gene therapy.
Career Highlights
Xiao has built a strong academic and research career, working at renowned institutions like the University of North Carolina at Chapel Hill and the University of Pittsburgh. His expertise and innovative thinking have made him a key figure in the development of advanced therapeutic strategies based on gene delivery systems.
Collaborations
Throughout his career, Xiao has collaborated with notable researchers, including Richard Jude Samulski and Forrest K Ferrari. These partnerships have led to significant advancements in the field, as they leverage their combined expertise to push boundaries in gene therapy and related research.
Conclusion
Xiao Xiao stands out as a trailblazer in the field of innovative therapies, holding 26 patents that demonstrate his prolific contributions to gene therapy and AAV technologies. His inventions promise to transform treatment methods for bleeding disorders and hold potential for broader applications in genetic medicine. As research continues, Xiao's work is likely to pave the way for future breakthroughs and improvements in patient care.