The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2017
Filed:
Jun. 28, 2016
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Assignee:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2006.01); A61K 48/00 (2006.01); C12Q 1/70 (2006.01); C07H 19/00 (2006.01); C07H 21/00 (2006.01); C12N 15/86 (2006.01); C07K 14/005 (2006.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01); C12N 7/00 (2006.01); A61K 35/76 (2015.01); C07K 14/705 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 35/76 (2013.01); A61K 38/1719 (2013.01); A61K 48/0058 (2013.01); C07K 14/005 (2013.01); C07K 14/4716 (2013.01); C07K 14/705 (2013.01); C12N 7/00 (2013.01); A61K 38/00 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14151 (2013.01);
Abstract
The present invention provides methods of achieving directed evolution of viruses by in vivo screening or 'panning' to identify viruses comprising scrambled AAV capsids having characteristics of interest, e.g., tropism profile and/or neutralization profile (e.g., ability to evade neutralizing antibodies). The invention also provides scrambled AAV capsids and virus particles comprising the same.