Company Filing History:
Years Active: 2007
Title: Innovations by Inventor Xiao-Ping Shi in Amyloid Precursor Protein Research
Introduction
Xiao-Ping Shi, based in Warrington, PA, is an innovative inventor known for his contributions to the field of amyloid precursor proteins and their relation to β-secretase activity. His cutting-edge research focuses on identifying inhibitors for β-secretase through modified substrates, potentially paving the way for advancements in therapeutic strategies for diseases like Alzheimer’s.
Latest Patents
Xiao-Ping Shi holds a patent titled "Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity." This patent outlines methods for identifying inhibitors of β-secretase that utilize modified β-secretase substrates. These substrates feature altered β-secretase cleavage sites, specifically differing amino acids in positions P2-P1-P1'-P2′ from their wild-type counterparts. The modifications enhance the efficiency of these substrates, making them more susceptible to enzymatic cleavage by β-secretase compared to their wild-type counterparts. The patent also includes recombinant polynucleotide molecules encoding these modified substrates, antibodies that recognize their cleavage products, stable cell lines, and transgenic animals expressing these modified substrates.
Career Highlights
Xiao-Ping Shi works at Merck & Co., Inc., a leading global pharmaceutical company renowned for its innovative research and development in medicine. His commitment to advancing the understanding of β-secretase activity through novel methods establishes him as a prominent figure in his field. His work at Merck contributes significantly to the development of new therapeutic approaches for neurodegenerative diseases.
Collaborations
Throughout his career, Xiao-Ping Shi has collaborated with esteemed colleagues, including Daria Hazuda and Elizabeth Chen Dodson. These collaborations highlight the interdisciplinary nature of his research and the teamwork required to drive innovation forward in the life sciences sector.
Conclusion
Xiao-Ping Shi’s contributions to the understanding of β-secretase activity through his innovative patent reflect his dedication to advancing medical science. His work not only enhances the potential for developing new therapies for Alzheimer's disease but also underscores the importance of collaboration in achieving groundbreaking inventions in the field of biomedicine.