Company Filing History:
Years Active: 2008-2017
Title: **Xianbin Yang: Innovator in Oligonucleoside Aptamers**
Introduction
Xianbin Yang is a prominent inventor based in Webster, Texas. His work primarily focuses on the development of innovative oligonucleoside phosphorothioate and phosphorodithioate aptamers. With a total of two patents to his name, Yang is making significant contributions to the field of molecular biology and immunology.
Latest Patents
Yang's latest patents showcase advanced methodologies in identifying and utilizing modified thioaptamers. One of his notable inventions is a patent for "Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting AP-1 transcription factors." This invention encompasses compositions and methods for creating a combinatorial library designed to discover modified thioaptamers that can influence the immune responses of host animals by targeting crucial transcription factors such as IL-6, NF-κB, and AP-1. It also addresses treatment methodologies for viral infections and the development of vaccines and vaccine adjuvants that modulate immune responses.
Another significant patent by Yang is focused on "Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries." This invention outlines methods to create a combinatorial library featuring multiple beads, each uniquely attached to a nucleic acid aptamer. These aptamers, which may be linked covalently to polystyrene beads, include a variety of chemistries such as phosphorothioate, phosphorodithioate, and methylphosphonate linkages, and can be in the form of single or double-stranded DNA, RNA, or even PNAs.
Career Highlights
Throughout his career, Xianbin Yang has established himself as a leading researcher in the field of aptamer technology. His patents reflect a deep understanding of the intricate relationships within the immune system and the potential for aptamers in therapeutic applications.
Collaborations
Xianbin Yang has worked alongside notable colleagues in his field, including David G. Gorenstein and Bruce A. Luxon. Their combined expertise contributes to the advancement of research within their respective disciplines, promoting innovative solutions in biotechnology and medical applications.
Conclusion
Xianbin Yang's contributions to the field of oligonucleoside aptamers highlight his role as an inventor dedicated to improving therapeutic methods and understanding immunological mechanisms. His patents not only showcase his innovative spirit but also pave the way for future research and development in targeted therapies and vaccine technology.