Company Filing History:
Years Active: 1992-1998
Title: Wlodzimierz Mandecki: Innovator in Diagnostic Assays
Introduction
Wlodzimierz Mandecki is a notable inventor based in Libertyville, IL (US). He has made significant contributions to the field of biotechnology, particularly in the development of diagnostic assays. With a total of 4 patents, Mandecki's work focuses on genetically engineered enzymes and their applications in various assays.
Latest Patents
One of Mandecki's latest patents involves genetically engineered enzymes and their conjugates for diagnostic assays. This invention relates to the creation of hybrid enzymes, such as an AP-epitope, which incorporates a foreign amino acid moiety near the active site of the starting enzyme. This modification allows the hybrid enzyme to bind with an analyte, thereby altering its enzymatic activity based on the presence or quantity of the analyte. Another embodiment of his work includes the introduction of cysteine near the active site of an AP enzyme, which serves as a conjugation point for ligands. These ligands can bind with antibodies or analytes, further modulating the enzymatic activity of the hybrid enzyme-ligand conjugate.
Additionally, Mandecki has developed improved methods for detecting antibodies in test samples using CKS-fusion proteins. These proteins are specific for antibodies and can be utilized in various assays, including screening, competitive, confirmatory, and immunodot assays. Test kits containing these CKS-fusion proteins are also part of his innovative contributions.
Career Highlights
Wlodzimierz Mandecki is currently associated with Abbott Laboratories Corporation, a leading company in the healthcare sector. His work at Abbott has allowed him to focus on advancing diagnostic technologies that have a significant impact on patient care.
Collaborations
Mandecki has collaborated with notable colleagues, including Timothy J Bolling and Sushil G Devare. These collaborations have further enhanced the development and application of his innovative technologies.
Conclusion
Wlodzimierz Mandecki's contributions to the field of biotechnology, particularly in diagnostic assays, demonstrate his commitment to innovation. His patents reflect a deep understanding of enzyme engineering and its practical applications in healthcare. Mandecki's work continues to influence the development of advanced diagnostic tools that improve patient outcomes.