William Markis

Title: The Innovations of William Markis in Pharmaceutical Formulations

Introduction

William Markis, an accomplished inventor located in Passaic, NJ, is known for his contributions to the field of pharmaceutical formulations. With a total of two patents to his name, Markis has made significant advances in the stability and purity of protein compositions, which are crucial in the pharmaceutical industry.

Latest Patents

Markis's latest patents focus on a novel process for reducing subvisible particles in a pharmaceutical formulation. The disclosures provide a stable protein composition that contains a surfactant and ensures very low levels of subvisible particles. Specifically, it details a composition that contains less than 400 subvisible particles of 10 microns or greater diameter per container, or fewer than 10,000 subvisible particles of 2 microns or greater per container. The method outlined for manufacturing this stable protein composition includes a unit operation designed to remove or diminish esterase activity that can degrade the surfactant. Techniques such as hydrophobic interaction chromatography, filtration, or mixed-mode chromatography are suggested as potential methods for achieving these results.

Career Highlights

Currently, Markis works at Regeneron Pharmaceuticals, Inc., a leader in the biopharmaceutical industry. His innovative approaches have contributed to advancements that enhance the effectiveness and safety of protein-based therapies. With his expertise, he has played a vital role in the development of formulations that are essential for various medical treatments.

Collaborations

Throughout his career, Markis has collaborated with notable colleagues, including Hanne Bak and John Mattila. These collaborations have fostered a creative environment, leading to groundbreaking developments in pharmaceutical sciences and enhancing the quality of patient care through improved drug formulations.

Conclusion

William Markis exemplifies the spirit of innovation that drives the pharmaceutical industry forward. His patents not only highlight his dedication to advancing pharmaceutical formulations but also reflect a commitment to improving the safety and stability of essential medications. As the industry continues to evolve, inventors like Markis remain instrumental in shaping the future of healthcare through their groundbreaking work.