The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 2019
Filed:
Oct. 08, 2015
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Hanne Bak, New York, NY (US);
John Mattila, Nyack, NY (US);
Ning Li, NewCanaan, CT (US);
Xiaolin Tang, Old Tappan, NJ (US);
Daniel Dix, LaGrangeville, NY (US);
Chen Li, White Plains, NJ (US);
William Markis, Passaic, NJ (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant. The unit of operation may be hydrophobic interaction chromatography or filtration, mixed mode chromatography, or the like.