Company Filing History:
3 out of 528 
1 out of 1,521 
3 out of 832,761 Years Active: 1998-2002
Title: **Inventor Spotlight: William K. Holloman**
Introduction
William K. Holloman, based in Yorktown Heights, New York, is a prolific inventor with a remarkable portfolio of six patents. His contributions to the field of genetics and molecular biology have significant implications for medical research, particularly in the areas of gene therapy and cancer treatment.
Latest Patents
Among his latest innovations is the patent concerning **Mammalian and Human REC2**, which focuses on mammalian recombinase genes (REC2) and their promoters. This invention reveals that the overexpression of REC2 in cells can enhance homologous recombination, especially when utilizing a DNA/RNA chimeric oligonucleotide. This process also sensitizes cells to the apoptotic effects of irradiation. Furthermore, the REC2 promoter, when paired with a robust enhancer, such as the SV40 enhancer, proves to be highly effective in promoting cell response post-irradiation. The research indicates that a radiation-inducible promoter can facilitate the sensitization of cells to radiation treatment by linking it to a gene that converts a prodrug into an active drug, for example, the herpes thymidine kinase gene.
Another notable patent by Holloman involves **Recombinant Helix Modification Recognition Proteins and Uses Thereof**, which presents the Hmp class of polypeptides, DNA sequences encoding these proteins, and their applications, particularly in methods and kits designed for mismatch detection, including mutation identification.
Career Highlights
Holloman's career has been marked by significant research and development efforts at prestigious institutions, including Thomas Jefferson University. His patents have not only contributed to academic knowledge but also have practical applications that may enhance therapeutic strategies in medicine.
Collaborations
Throughout his career, Holloman has collaborated with renowned researchers, including Eric B. Kmiec and Michael C. Rice. These partnerships have likely played a crucial role in driving innovative research and advancing the projects he has been involved in.
Conclusion
William K. Holloman stands as a notable figure in the world of innovation and invention, particularly in the realm of molecular biology. His six patents reflect his dedication to advancing our understanding of genetic mechanisms and their applications in medicine. Through his meaningful contributions, Holloman continues to inspire and influence future generations of inventors and researchers.