North Wales, PA, United States of America

William J Miller



Average Co-Inventor Count = 2.9

ph-index = 7

Forward Citations = 229(Granted Patents)


Company Filing History:


Years Active: 1976-1998

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15 patents (USPTO):Explore Patents

Title: Innovations of William J. Miller in Vaccine Development

Introduction

William J. Miller is a prominent inventor based in North Wales, PA, known for his significant contributions to the field of vaccine development. With a total of 15 patents to his name, Miller has focused on creating innovative solutions to combat infections caused by Streptococcus pneumoniae. His work has the potential to save countless lives by improving vaccine efficacy.

Latest Patents

Miller's latest patents include a groundbreaking process for making capsular polysaccharides from Streptococcus pneumoniae. This process results in type-specific capsular polysaccharide preparations that have an average of less than 1000 oligosaccharide repeat units per molecule. The products exhibit polydispersities between 1.0 and 1.4, intrinsic viscosities between 0.6 and 3.0 dL/g, and less than 3% contamination by group-specific C-polysaccharide. These novel polysaccharide products are particularly useful in the preparation of vaccines, especially covalent conjugates linked to T-cell stimulatory carrier proteins. Additionally, Miller has developed a novel pneumococcal polysaccharide conjugate vaccine that comprises partially hydrolyzed, highly purified capsular polysaccharide linked to an immunogenic carrier protein. This conjugate is designed to prevent pneumococcal infections and elicits protective immune responses in young children and infants who typically cannot respond effectively to polysaccharide alone.

Career Highlights

Miller's career has been marked by his dedication to research and innovation in the pharmaceutical industry. He is currently employed at Merck & Company, Inc., where he continues to advance vaccine technology. His work has not only contributed to scientific knowledge but has also had a direct impact on public health.

Collaborations

Miller has collaborated with notable colleagues, including William J. McAleer and William M. Hurni. These partnerships have fostered a collaborative environment that enhances the development of effective vaccines.

Conclusion

William J. Miller's innovative work in vaccine development exemplifies the critical role of inventors in advancing medical science. His contributions are paving the way for more effective vaccines that can protect vulnerable populations from serious infections.

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