The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 22, 1997
Filed:
May. 20, 1994
Stephen Marburg, Metuchen, NJ (US);
Richard L Tolman, Warren, NJ (US);
Peter J Kniskern, Lansdale, PA (US);
William J Miller, North Wales, PA (US);
Arpi Hagopian, Lansdale, PA (US);
Charlotte C Ip, Blue Bell, PA (US);
John P Hennessey, Jr, Dublin, PA (US);
Dennis J Kubek, Salem, WV (US);
Pamela D Burke, Lansdale, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
A novel conjugate vaccine comprising partially hydrolyzed, highly purified, capsular polysaccharide (Ps) from Streptococcus pneumoniae bacteria (pneumococci, Pn) linked to an immunogenic carrier protein, is produced by a new process. The conjugate is useful in the prevention of pneumococcal infections. Vaccines comprising a mixture of from one to ten different pneumococcal polysaccharide-immunogenic protein (Pn-Ps-PRO) conjugates induce broadly protective recipient immune responses against the cognate pathogens from which the polysaccharide components are derived. Young children and infants younger than 2 years old, normally unable to mount a protective immune response to the Pn-Ps alone, exhibit protective immune responses upon vaccination with these Pn-Ps-PRO conjugates.