Location History:
- Rowley, MA (US) (1994 - 1996)
- Wenham, MA (US) (1994 - 2003)
Company Filing History:
Years Active: 1994-2003
Title: The Innovations of William E. Jack
Introduction
William E. Jack is a notable inventor based in Wenham, MA (US), recognized for his contributions to the field of molecular biology. With a total of 7 patents, he has made significant advancements in the use of nucleic acids and proteins.
Latest Patents
One of his latest patents is titled "Use of site-specific nicking endonucleases to create single-stranded regions and applications thereof." This invention focuses on utilizing site-specific nucleic acid nicking enzymes to generate single-stranded regions within duplex nucleic acids. These single-stranded regions can be designed as gaps within the duplex or as terminal single-stranded regions. Such configurations facilitate the linkage of various elements through base-pairing with complementary single-stranded regions. This method is particularly useful for the ordered assembly of DNA modules, which can be employed to create cloning or expression vectors. Additionally, it aids in attaching detection probes and purifying DNA molecules that contain the single-stranded region.
Another significant patent by Jack is "Modified proteins comprising controllable intervening protein sequences." This invention pertains to modified proteins that include a controllable intervening protein sequence (CIVPS) inserted into or adjacent to a target protein. The CIVPS can be excised or cleaved under specific conditions, such as temperature changes, light exposure, or chemical treatments. This technology allows for the purification of target proteins in a streamlined one-step protocol.
Career Highlights
William E. Jack is currently associated with New England Biolabs, Inc., where he continues to innovate in the field of biotechnology. His work has had a profound impact on the development of new methodologies in molecular biology.
Collaborations
Jack has collaborated with esteemed colleagues, including Donald G. Comb and Francine B. Perler, further enhancing the scope and impact of his research.
Conclusion
William E. Jack's contributions to the field of molecular biology through his innovative patents demonstrate his commitment to advancing scientific knowledge and technology. His work continues to influence the development of new tools and methods in biotechnology.