William B Guggino

Title: William B Guggino: Innovator in Urate Transport and Cystic Fibrosis Treatment

Introduction

William B Guggino is a prominent inventor based in Baltimore, MD (US). He has made significant contributions to the field of medical research, particularly in the modulation of urate transport and the treatment of disorders associated with calcium-activated chloride channels (CaCC). With a total of 4 patents, Guggino's work has had a profound impact on understanding and treating conditions such as hyperuricemia and gout.

Latest Patents

Guggino's latest patents include groundbreaking research on the modulation of ABCG2-mediated urate transport to treat hyperuricemia and gout. This patent highlights the use of genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with serum urate levels and gout. His findings reveal that the ABCG2 gene encodes a previously unknown urate efflux transporter located in the brush border membrane of kidney proximal tubule cells. Additionally, he has developed spiperone derivatives that are useful in stimulating CaCC and treating disorders related to this channel, including cystic fibrosis.

Career Highlights

Throughout his career, Guggino has worked with esteemed institutions such as The Johns Hopkins University and Targeted Genetics Corporation. His research has not only advanced scientific understanding but has also paved the way for potential therapeutic applications.

Collaborations

Guggino has collaborated with notable colleagues, including Terence R Flotte and Barrie J Carter. These partnerships have further enriched his research and contributed to the development of innovative treatments.

Conclusion

William B Guggino's contributions to medical research, particularly in urate transport and cystic fibrosis treatment, underscore his role as a leading inventor in the field. His patents and collaborations reflect a commitment to advancing healthcare solutions.