Company Filing History:
Years Active: 2001-2002
Title: Whei-Kuo Wu: Innovator in Nucleic Acid Detection Technologies
Introduction
Whei-Kuo Wu is a prominent inventor based in San Diego, CA, known for his significant contributions to the field of nucleic acid detection technologies. With a total of 5 patents, Wu has developed innovative methods that enhance the efficiency and accuracy of nucleic acid processing.
Latest Patents
One of his latest patents is titled "Sample processing to release nucleic acids for direct detection." This invention describes compositions and methods for releasing nucleic acids from cells in a form that is suitable for labeling, capture, amplification, or detection in a single reagent addition step. The compositions include a lipid, membrane fluidizing compound, enzyme for degrading cell structure, metal chelators, or one or more nucleic acid probes or primers complementary to the nucleic acid to be detected. The compositions are non-denaturing and non-inhibitory of enzymes or proteins that are used in nucleic acid release, amplification, labeling, or detection. The invention also provides kits for performing the above methods.
Another notable patent is "Method of labeling a nucleic acid amplicon with simultaneous contamination prevention." This invention relates to methods of amplifying nucleic acids to minimize contamination by products of earlier amplification reactions. More particularly, it relates to methods of using nucleic acid labels that inhibit further amplification of the amplicon, and compositions that are useful to accomplish this task. In particular, the present invention relates to photoreactive complexes of a binding ligand, a binding enhancer, and a label.
Career Highlights
Whei-Kuo Wu is currently associated with Applied Gene Technologies, Inc., where he continues to push the boundaries of nucleic acid research and technology. His work has been instrumental in developing solutions that address critical challenges in the field.
Collaborations
Wu has collaborated with notable colleagues, including Nanibhushan Dattagupta and C Nagaraja Sridhar, who have contributed to his research endeavors.
Conclusion
Whei-Kuo Wu's innovative work in nucleic acid detection technologies has made a significant impact in the field. His patents reflect a commitment to advancing scientific knowledge and improving methodologies in nucleic acid processing.